To me it seams like the Colts are the overall better team. They can control the clock and pick people apart with the passing game. On the other hand, the Saints have so many playmakers on the team its ridiculous. They have 3 receivers that can flat out run past you and Reggie Bush is insane. With that being said, I think it will be a close game, or the Colts will win by a few TD's.
Prediction: Peyton Manning will pick apart the Saints defense early and put the game away in the fourth quarter. Peyton will throw for over 300 and 4 TD's with a rushing TD by either Addai or Brown. The Saints will score on a big play early and late in the game, Brees Throwing for 2 TDs and about 250 yards, add another TD by Bush (either big return or a rushing TD) then factor in a few field goals and we will have a final of 38-27 in favor of the Indianapolis Colts.